Tying Up in Horses: Causes, Symptoms & Management

Horses are extraordinary athletes, graceful companions, and for many in the United States, valued partners in work and sport. Yet, despite their strength, these animals are susceptible to various muscle disorders. One such common condition is tying up.

For horse owners, trainers, and caretakers, understanding this distressing syndrome can mean the difference between a happy, healthy mount and one that suffers recurrent pain and disability. 

In this guide, we will break down what tying up in horses is, how you should recognize its signs, and its causes. 

What Is Tying Up in Horses?

Tying up in horses is a lay term that describes a collection of muscle disorders characterized by painful muscle contractions, stiffness, and even muscle breakdown. Also known as exertional rhabdomyolysis or azoturia, this condition commonly affects a horse's large muscle groups, especially after exercise, causing both discomfort and a decrease in performance.

But what is tying up in horses on a deeper level? Essentially, the horse’s muscle cells become damaged and leaky, releasing their contents (such as myoglobin) into the bloodstream. If you do not manage it properly, it may result in severe complications such as kidney damage.

Recognizing the Signs: How to Spot a Tying Up Episode

Spotting the early tying up symptoms in horses​ is crucial for prompt intervention and minimizing lasting damage. Some of the most common signs of tying up in horses​ include:

  • Muscle Stiffness: The horse moves begrudgingly, with a rigid, stilted gait.
  • Sweating: Excessive sweating, even after only mild exercise.
  • Pain Responses: Restlessness, pawing, or unwillingness to move.
  • Dark Urine: A result of muscle breakdown products passing through the kidneys.
  • Elevated Heart and Respiratory Rates: Possibly accompanied by anxiety or distress.

Common Triggers and Risk Factors of Tying Up in Horses

Understanding what causes tying up is key to prevention and better management. Though multiple factors may be involved, some of the most common triggers and risk factors include:

  • Overexertion: Working a horse beyond its fitness level or after a period of rest.
  • Diet Imbalances: High grain or starch diets, especially if not matched by adequate exercise.
  • Genetic Predisposition: Some lines, notably Quarter Horses and Thoroughbreds, are more susceptible.
  • Electrolyte Imbalances: Improper hydration or lack of essential minerals.
  • Hormonal Factors: Especially in fillies and mares.


The complexity of muscle metabolism means that tying up often arises from individual combinations of these risk factors.

What are the Types of Tying Up in Horses

"Tying up" is a broad term that encompasses several muscle-related conditions in horses, each stemming from different underlying causes, including the following:

1. Polysaccharide Storage Myopathy (PSSM)

PSSM is a hereditary muscle disease, most commonly seen in stock breeds. 

Horses with PSSM accumulate abnormal polysaccharides (a type of sugar) in their muscles, which interfere with normal muscle function and lead to tying up episodes.

2. Recurrent Exertional Rhabdomyolysis (RER)

More prevalent among Thoroughbreds, Standardbreds, and Arabs, RER is characterized by repeated episodes of muscle stiffness, especially during training or competition. 

Unlike PSSM, RER often relates to the horse’s nervous temperament and disturbances in muscle calcium regulation.

3. Sporadic Exertional Rhabdomyolysis

This type occurs sporadically, typically due to overexertion, especially after inadequate conditioning or sudden increases in workload.

In summary, while PSSM is a storage issue and genetically influenced, RER arises from disturbances in muscle signaling, with triggers rooted more in the environment and management.

Managing and Preventing Tying Up: Nutrition, Exercise, and Care

1. Nutrition Optimization

  • Lower Starch Diets: Reducing nonstructural carbohydrates (NSC) helps prevent excess glycogen accumulation, particularly in horses with PSSM.
  • Increase Fat Content: Fats provide a stable energy source for horses prone to tying up.
  • Mineral Balance: Supplement with electrolytes and minerals, as deficiencies can exacerbate muscle problems.

2. Consistent Exercise Routine

  • Regular Turnout and Exercise: Ensures muscle health and prevents the build-up of glycogen stores.
  • Gradual Warm-Up: Prepares muscles for work, lowering the risk of acute episodes.
  • Avoid Sudden Workload Changes: Sudden increases in intensity or duration can trigger episodes.

3. Medical and Supportive Treatment

  • Immediate Rest: At the first sign of tying up, stop exercise and allow the horse to rest.
  • Pain Management: Non-steroidal anti-inflammatories (NSAIDs), as prescribed by your vet.
  • Fluid Therapy: Especially in cases of severe muscle breakdown to support kidney function.
  • Vitamin and Supplementation: Consider specific products like vitamin E and selenium if deficiencies are detected.

4. Environmental and Lifestyle Adjustments

  • Stress Reduction: Minimize changes in routine, social stress, and transport as these can trigger episodes in susceptible horses.
  • Hormonal Management: In mares with apparent cycle-linked episodes, discuss possible interventions with your veterinarian.

Final Thoughts

The importance of muscle health in horses cannot be underestimated. 

Every owner should endeavor to make informed decisions to support their horse’s well-being. This can be achieved through nutrition, thoughtful management, and being your horse's first and best advocate. Always consult with your veterinarian before making sudden changes to your horse’s routine or management plan.

Connect with Med-Vet Pharmaceuticals via our website today to grab the best nutritional supplement for your horse. 

MVP provides a number of products that include nutrients like vitamin E, selenium, lysine and magnesium to help support muscle health and wellness.

Take a moment to check out our full supplement range. Not sure which one fits your horse’s routine? Just contact us at 833-809-4848, and we’ll gladly guide you.

FAQs

Q1. What is tying up in horses, and how does it affect muscle function?

Ans. Tying up in horses refers to conditions where muscle fibers become abnormally contracted. This is due to metabolic disturbances, affecting muscle function by causing stiffness, pain, and potentially leading to muscle cell breakdown.

Q2. What are the early warning signs of a tying up episode?

Ans. Early signs include muscle stiffness, reluctance to move, and heavy sweating. Recognizing these promptly is vital for preventing severe complications.

Q3. What are the most common causes and triggers of tying up in horses?

Ans. Common causes include genetic predisposition, high-starch diets, sudden increases in exercise, electrolyte imbalances, and hormonal changes.

Q4. What is the difference between PSSM and RER in horses?

Ans. PSSM is a hereditary disorder causing abnormal sugar storage in muscle cells, while RER involves disruptions in muscle activity and is often linked with stress or excitement, especially in certain breeds.

Q5. How do veterinarians diagnose muscle disorders like tying up?

Ans. Diagnosis relies on blood tests (elevated CK/AST), urinalysis (detecting myoglobinuria), muscle biopsies for PSSM confirmation, and sometimes genetic testing.

Heather Steege
Article By
Heather Steege
Vice President at MVP
Vice President at MVP, brings over 30 years of equine nutrition experience. Raised in the equine industry, she is dedicated to delivering top-quality supplements, education, and customer care.